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Granulocytic sarcoma is an uncommon manifestation of myelogenous leukemias in which focal masses of immature myeloid cells from the granulocytic lineage infiltrate bone and soft tissue. In 4 following cases, 2 cases were died within 3 months. It consists of immature cells of the granulocytic series. Orbital myeloid sarcoma (chloroma) as an initial symptom of acute myeloid leukemia (AML), is a rare medical condition. Chloroma may be regarded as an unusual form of myeloid leukemia in which a prominent feature is the deposition of tumour-like masses of myeloid cells in the skeleton (especially in the subperiosteal zones), lymph nodes and viscera. Granulocytic sarcoma of the orbit, also known as chloroma, is an extramedullary form of myelogenous leukemia. Children with acquired orbital disorders most commonly present with signs and symptoms of a mass leading to proptosis or non-axial displacement, soft tissue signs, and/or a palpable orbital mass. CONCLUSIONS: Orbital chloroma can be easily misdiagnosed as other types of malignant orbital tumor in children. To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Sixteen cases were referred to the department of hematology for treatment. Chloroma may precede the onset of leukemia or occur in bone marrow remission. The mass sizes varied from a mean diameter of 1.3 to 5.8 cm (average, 2.6 cm). Radiologic images are essential for determine specific diagnosis in most cases of pediatric orbital pathology. (a) Axial CT image in soft-tissue window reveals large irregular soft-tissue mass in the left orbit.The mass is poor-demarcated and heterogeneous density. CONCLUSIONS: Orbital chloroma can be easily misdiagnosed as other types of malignant orbital tumor in children. The diagnosis of orbital chloroma can be established by radiology and hematological examinations. Radiology 190:698–702 PubMed Google Scholar 4. Orbital blowout fracture and vitreous hemorrhage All Posts ... •1853: King initially called it chloroma, because typical forms have a green color caused by high levels of myeloperoxidase in the immature cells. Zimmermann LE, Font RL (1975) Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma). This tumor can be treated by chemotherapy and radiotherapy. It is most common in the pediatric population and may present at any time in the course of the disease, either concurrently with the onset of leukemia or during a remission or relapse. cytic sarcoma (chloroma): CT Manifestations. Occurrence is more common in acute rather than chronic myelogenous leukemia. There was diffuse hyperostosis of the … Bulas RB, Laine FJ, Das Narla L. Bilateral orbital granulocytic sarcoma (chloroma) preceding the blast phase of acute myelogenous leukemia: CT findings. Am J Ophthalmol 1975; 80:975-990. We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. Orbital tumors in children are very rare and radiologic image, as magnetic resonance, is extremely important for correct diagnosis. The masses were most commonly located in the orbital cavity (n=8); other locations included lymph nodes (n=5) and palatine/pharyngeal/lingual tonsils (n=3). Pediatr Radiol 1995; 25:488-489 [Google Scholar] Radiology Review Manual (Dahnert, Radiology Review Manual),2004, (isbn 0781766206, ean 0781766206), by Dahnert W. F. ... Waller RR: Orbital … This tumor can be treated by chemotherapy and radiotherapy. But the presence of chloroma does not alter the rate of remission after chemotherapy . (b) Coronal CT image in bone window reveals bone destruction in the medial orbital wall.The lesion extends into the ethmoid sinuses and the nasal cavities. High risk subgroup of acute The tumor extends into the left ethmoid sinus. Intracranial chloroma may exhibit intermediate or high attenuation with moderate edema and peripheral contrast enhancement. Orbital rhabdomyosarcoma. Multiple lesions were found in 6 patients. Sino-orbital granulocytic sarcoma is a rare manifestation of leukemia. Granulocytic sarcoma, also known as chloroma or extramedullary myeloblastoma, is a rare solid tumor composed of primitive precursors of the granulocytic series of WBC that include myeloblasts, promyelocytes, and myelocytes [].This tumor was first described by Burns in 1811. that the mass-like density represents chloroma. Radiology 1985;155: 167-170 2. RASHMI M NAGARAJU, BHIMARAO (2015) Chloroma of Orbit: A Rare Initial Presentation in A Case of Acute Myeloid Leukemia. The shapes of the tumors were ovoid in 12 patients and irregular Babacan E, Gozdasoglu S, et al. Keywords: orbital, tumors, proptosis, hemangioma, rhabdomyosarcoma, neuroblastoma, chloroma, synovial sarcoma, magnetic ressonance imaging, radiology It is most common in the pediatric population and may present at any time in the course of the disease, either concurrently with the onset of leukemia or during a remission or relapse. Histological diagnosis can be difficult in patients with poorly differentiated orbital tumours and no evidence of systemic leukaemia. In 1811, Allen Burns first reported this as a green tumour involving the orbit.1 The characteristic green colour is derived from the enzyme myeloperoxidase (MPO). Orbital granulocytic sarcoma (chloroma), a rare tumor of immature myeloid cells, has nonspecific clinical and radiological features that make it a diagnostic challenge. ... (myeloid sarcoma or chloroma). Kao SCS, Yuh WTC. AIM Orbital granulocytic sarcoma is a localised tumour composed of cells of myeloid origin. 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